Nine distinct contemporary methods plus an honest note on the historical rhythm method. For each: developer, biomarkers, peer-reviewed effectiveness, and the user profile it serves best.
The Marquette Method
Dana's Method
Prof. Richard J. Fehring, PhD, RN, FAAN · Boland Institute for Natural Family Planning, Marquette University College of Nursing · 1990s–present
A sympto-hormonal method combining objective urinary-hormone readings from the ClearBlue Easy Fertility Monitor (estrone-3-glucuronide and luteinizing hormone) with optional cervical-mucus charting. The Marquette algorithm defines the fertile window using monitor output plus optional mucus confirmation and has dedicated sub-protocols for regular cycles, postpartum / breastfeeding, and perimenopause. Online charting, a smartphone app, and certified-instructor support (Marquette Method Certified Professional, MMCP). Prof. Dana Rodriguez served as a research assistant at the Marquette Institute for Natural Family Planning and is a co-author on one of the method's foundational effectiveness papers — see the Deep Focus section below.
Perfect use98.4%
Typical use~98%
Key studyMu, Fehring, Bouchard 2022
JournalLinacre Quarterly 89(2)
Best for: women wanting objective, technology-assisted confirmation; couples uncomfortable with mucus-only methods; women with irregular cycles; breastfeeding and perimenopausal populations (Marquette has specific sub-protocols for each).
Creighton Model & NaProTECHNOLOGY
Mucus + diagnostics
Prof. Thomas W. Hilgers, MD, FACOG · Saint Paul VI Institute, Omaha · 1976–present
Standardized, objective external observations of cervical-mucus discharge charted by the woman using a precise vocabulary (sticky, tacky, stretchy, lubricative, clear, cloudy, peak-type). NaProTECHNOLOGY extends the system into medical diagnosis and treatment for endometriosis, PCOS, luteal phase deficiency, recurrent miscarriage, and unexplained infertility.
Method eff.99.5%
Use eff.96.8%
Key studyHilgers & Stanford 1998
Best for: couples pursuing restorative reproductive medicine; subfertility workup.
Billings Ovulation Method
Mucus-only
Drs. John and Evelyn Billings, with Prof. James Brown · Australia · 1953–present
The first cervical-mucus-only method. The woman observes the sensation and appearance of mucus at the vulva, records it in standardized symbols, and applies the Billings rules to identify the fertile window. No technology required. Internationally taught.
Perfect use97.4–100%
Key studyWHO multicenter 1981
Countries5 (India, Ireland, El Salvador, Philippines, New Zealand)
Best for: women seeking a technology-free, low-cost, internationally-established method.
Sympto-Thermal Method
Multi-biomarker
John & Sheila Kippley (Couple to Couple League) · European Sensiplan (Arbeitsgruppe NFP) · 1971–present
Combines cervical mucus, basal body temperature, and optionally cervical changes. The double-check design is what makes STM the most effective modern NFP method in the peer-reviewed literature — the European Sensiplan study of 900 women across 17,638 cycles found a method-failure Pearl index of 0.4 per 100 woman-years.
Pearl index0.4/100 WY
Cycles studied17,638
Key studyFrank-Herrmann 2007
JournalHuman Reproduction 22(5)
Best for: couples wanting a robust, self-verified double-check system without monitor costs.
FEMM Health
Hormones + medicine
Anna Halpine & Prof. Pilar Vigil, MD, PhD · Reproductive Health Research Institute · 2012–present
A sympto-hormonal method with an integrated medical-management arm. Cervical-mucus charting plus optional urinary LH test strips. The FEMM Medical Management program trains physicians to diagnose reproductive disorders from FEMM charts. A teenFEMM curriculum delivers the framework as adolescent health-literacy education.
Published asSympto-hormonal category
Key reviewDuane, Stanford, Porucznik, Vigil 2022
JournalFrontiers in Medicine 9:858977
Best for: women seeking integrated reproductive healthcare; adolescents (through teenFEMM); women with hormonal symptoms.
Standard Days Method
Calendar-plus
Institute for Reproductive Health, Georgetown University · Prof. Victoria Jennings · 2002
A simplified calendar-based method (for women with cycles between 26 and 32 days). Days 8–19 are treated as fertile. Typically paired with CycleBeads — a color-coded counting tool. Useful in resource-constrained contexts; not considered true modern NFP by USCCB because it does not observe biomarkers in real time.
Perfect use95%
Typical use88%
RequirementCycles 26–32 days
Best for: developing-world contexts; women with regular 26–32 day cycles wanting a simple approach.
TwoDay Method
Simplified mucus
Institute for Reproductive Health, Georgetown University · 2004
A simplified single-biomarker method. The woman asks two questions: “Did I note secretions today?” and “Did I note secretions yesterday?” A “yes” to either indicates fertility. Developed as an accessible alternative to Billings for resource-constrained settings.
Correct use96.5%
Typical use86.4%
Key studyArevalo, Jennings, Nikula, Sinai 2004
Best for: resource-constrained settings; simpler alternative to Billings.
Lactational Amenorrhea Method (LAM)
Postpartum
1988 Bellagio Consensus Conference
Birth-spacing method for the first six months postpartum. Three criteria must all be true: exclusive or near-exclusive breastfeeding, amenorrhea (no return of menses), and less than six months postpartum. When all three conditions hold, breastfeeding itself suppresses ovulation with >98% reliability. Intended as a bridge to another method as the three criteria lapse.
Effectiveness>98%
CriteriaAll three required
Key studyKennedy, Rivera, McNeilly 1989
Best for: exclusively-breastfeeding mothers in the first six months after birth.
Rhythm Method (Knaus-Ogino)
Historical only
Kyusaku Ogino (1924) & Hermann Knaus (1928)
The 1930s calendar-based predecessor of modern NFP. Predicted fertile days by averaging prior cycle lengths; observed no real-time biomarker. Largely discontinued after better methods emerged in the 1950s. We name it here so readers do not confuse it with modern NFP. USCCB explicitly states that calling calendar-only methods “NFP” is inaccurate.
Typical failure13–20/100 WY
StatusSuperseded
If someone tells you NFP is “the rhythm method,” they are 90 years out of date.